Once the vessel is free of ice residue, the drying of samples located at the edge of the container is complete. Lyophilizer Chamber Sizes and Dimensions:ĭetermining the primary drying end point for each sample can be a challenge. Bulk drying is not suitable for samples prone to cross-contamination or changes in atmospheric conditions. As heat is transferred to the samples through conduction from the shelf or tray, the product must be spread across the area to a uniform thickness to prevent changes in heating rates.
Rather than drying products sealed in individual vessels, bulk drying involves spreading the products across the surface area of a shelf or tray. As each vessel has a direct connection to the collector, manifold drying is more efficient than tray drying.Ĭompare: Purge Valve | Mini Chamber Purge Valve F3 - Bulk Lyophilizer Freeze Drying Chambersįor stable products resistant to changes in moisture or oxygen levels, bulk drying chambers permit precise control of temperature and heat input. Manifold systems accommodate vessels of different sizes to allow drying of multiple products or batches during a single run. Manifolds are connected to individual ports on the manifold after the pre-frozen samples are removed from a storage freezer or low-temperature water bath. Manifold drying provides a flexible alternative to tray drying for small volume samples with high eutectic and collapsed temperatures, vials, ampules, or frost-free flasks. View: Labconco Freezone Stoppering Tray Dryers F2 - Lyophilizer Freeze Dryer Flask Manifolds Although slight variations in drying conditions may be experienced for samples located near the clear front door of the tray dryer, the samples are heated under the same protocol and conditions to ensure maximum uniformity. Labconco Stoppering Tray Dryers are ideal for batch drying operations involving pre-frozen samples from the same, or similar, production lot the vessels are placed in a tray dryer to ensure uniform conditions. (back to chart) F1 - Lyophilizer Stoppering Tray Dryers View Price: FreeZone 2.5 Liter -84C Benchtop Freeze Dryers A3 - 105 Degrees Celsius Lyophilizer Dry FreezersĪ collector coil cooling to -105 degrees is optimal for low eutectic point samples stored in methanol or ethanol.į - Lyophilizer Bulk Trays, Flasks, Tubes and Accessories View Price: FreeZone 18 Liter -50C Console Freeze Dryers by Labconco A2 - 84 Degrees Celsius Lyophilizer Dry FreezersĪ collector coil cooling to -84 degrees is ideal for low eutectic point samples stored in DI water or acetonitrile. (Optional: Solvent & Collector Freezing Points: Table Shown Here) A1 - 50 Degrees Celsius Lyophilizer Dry FreezersĪ collector coil cooling to -50 degrees is optimal for freeze drying aqueous samples stored in DI or nuclease-free water. Benchtop and console Lyophilizers are available in a range of capacities. Low Eutectic Pointįreeze dry systems for low eutectic point samples have a working temperature of -86☌. Aqueous Onlyįreeze dry systems for aqueous samples have a working temperature of -50☌. To ensure the effective capture of sample vapor during sublimation, the collection coil must maintain a temperature of 15 – 20 degrees colder than the sample’s freezing point. The lyophilizer collector coil acts as a cold trap to collect moisture vapor eluting from the frozen product. Freeze drying for long term storage of dry powder with live microorganisms (probiotics / bacteria)Ī - Lyophilizer Collector Coil Temperature.Increase stability of therapeutic proteins (monoclonal antibodies).
Lyophilization, or freeze drying, is a common technique used in the pharmaceutical and food industries to vacuum freeze samples for long-term, ambient storage.
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